Remdesivir approved for COVID-19 treatment in Japan

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Remdesivir (Photo: AFP)

Japan, however, as yet does not know when it will get its first doses of remdesivir or how much, the health ministry official said.

The country reached the decision just three days after the U.S. drugmaker filed for fast-track approval for the treatment.

“There has so far been no coronavirus medicine available here so it is a significant step for us to approve this drug,” Reuters quoted a Japanese health ministry official said at a press briefing. Remdesivir will be give to patients with severe COVID-19 symptoms, he added

Prime Minister Shinzo Abe said last week the government was getting ready to give a speedy green light to the experimental drug developed by U.S. firm Gilead Sciences, Japan Today reported.

The U.S. go-ahead came after a major clinical trial showed remdesivir -- originally developed to treat Ebola -- shortened the time to recovery in some patients by a third.

Japan, with just over 16,000 infections and under 800 deaths, as of May 8, has recorded fewer cases than other major industrialized nations.

However, a steady rise in cases has put pressure on medical facilities in some parts of the country, and a drug that helps patients recover more quickly could help in freeing up hospital beds.

On Monday, Japanese Prime Minister Shinzo Abe extended a month-long state of emergency until the end of May in an attempt to slow the spread of the coronavirus.

With no other approved treatments for COVID-19, interest in remdesivir, the first drug shown to help fight COVID-19, is growing around the world. Administered by intravenous infusion, it was granted authorisation last week by the U.S. Food and Drug Administration for emergency use for the disease caused by the novel coronavirus.

Gilead says the drug has improved outcomes for people suffering from the respiratory disease and has provided data suggesting it works better when given in the early stages of infection.

(Photo: CNBC)

As for Avigan, developed by Japanese firm Fujifilm Toyama Chemical, Suga said the government "aims to approve it this month" if a clinical trial involving 100 patients proves effective.

The drug, whose generic name is favipiravir, was approved for use in Japan in 2014 but only in flu outbreaks that are not being effectively addressed by existing medications.

It is not available on the market and can only be manufactured and distributed at the request of the Japanese government.

Favipiravir, which can be taken orally as a pill, works by blocking the ability of a virus to replicate inside a cell.

Remdesivir incorporates itself into the virus's genome, short-circuiting its replication process.

Avigan has been shown in animal studies to affect fetal development, meaning it is not given to pregnant women, Japan Today reported.

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