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The COVID-19 pandemic has claimed the lives of millions of victims (Photo: Nordic Life Science)

The patient's death after 154 days of battling

According to Daily Mail, the male patient had a severe autoimmune disorder that prevents unnecessary blood clotting. He also suffered from a complication of the autoimmune disorder known as diffuse alveolar hemorrhage, in which blood vessels bleed into the lungs.

In an effort to keep these life-threatening conditions, the man was on blood thinners, steroids and drugs that suppress the immune system, putting him at high risk for coronavirus, for multiple reasons.

He came to a hospital with a fever and promptly tested positive for coronavirus.

Doctors began treating the man with a five-day course of the antiviral remdesivir and bumped up the dosage of his steroids out of concern that he might be bleeding into the air sacs of his lungs, due to his pre-existing condition.

By day five, he was discharged, and did not need supplemental oxygen.

But his improved state didn't last long. Over the course of the next 62 days, he was supposed to be quarantined at home, but instead had to be readmitted to the hospital three times for abdominal pain, trouble breathing and fatigue.

Each time, his blood-oxygen levels were below normal and his doctors remained on edge that he would suffer pulmonary bleeds, and his steroid dose was bumped up to try to prevent them.

However, his viral load of SARS-CoV-2, which causes COVID-19, fell lower over the course of that 62-day period - an encouraging sign he would clear the infection.

But 105 days after his first diagnosis, the man wa admitted again, with the same issues, and a higher viral load, 'which caused concern for a second COVID-19 recurrence,' write the study authors.

He was given another course of remdesivir and finally tested negative for coronavirus afterward, but he wasn't out of the woods and remained on treatment.

A little over a month later, the man was positive again, which 'caused concern for a third recurrence of COVID-19.'

This time, he was given Regeneron's experimental antibody cocktail.

But for this man, it was not the 'cure' that President Trump claimed it had been for him.

A week after getting the antibody drug, the man had to be put on a ventilator. His viral load was nearly as high as the previous test had suggested, and he had developed a fungal infection in his lungs.

Despite treatment with more remdesivir and antifungal, the died, 154 days after his initial positive test.

The virus has mutated at a quick pace inside the patient's body during the 5 months of infection (Photo: Technology Networks)

Scientists found alarming virus evolution in his body

'Although most immunocompromised persons effectively clear SARS-CoV-2 infection, this case highlights the potential for persistent infection and accelerated viral evolution associated with an immunocompromised state,' the study authors wrote.

It's unclear whether the mutations to the spike protein the strain of virus the researchers found in the man would make it more or less infectious, more deadly or even more treatment-resistant.

But, the case is a worrying reminder that people - especially those with weakened immune systems - can be reservoirs, where the virus can become a stronger form of itself, and from which it could jump to others and potentially evade treatments and vaccines, according to the case report published Wednesday in the New England Journal of Medicine (NEJM).

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